Select two roses that you want to cross-pollenate. The blooms should not be too tight, perhaps about one-half to 3/4 open. Carefully peel off all the petals. The rose stamens inside should look golden yellow and fresh. With sterile tweezers or cuticle scissors, carefully remove all the stamens at the base of the rose hip, so you do not damage the pollen sacs (anthers). Place the rose stamens into separate, clean film canisters, and place the canisters in a dry place, but not in direct sunlight.
Some people don't bother to take the time to do this, but others do. While the rose seeds are soaking, you will see that some sink to the bottom and some float on the top. The seeds that float are sometimes not viable, so you might want to throw them away. The rose seeds that sink are said to be the good ones, and are the ones to plant. There are pros and cons to this theory, and many rose hybridizers simply plant all the rose seeds that are harvested.
Fertilizer: Roses are heavy feeders, and will benefit from a steady supply of nitrogen, phosphorus and potassium. You can provide these nutrients with either liquid or granular fertilizers, at a ratio of approximately 5-8-5. In most cases, regular applications of compost, rotted manure, fish emulsion and seaweed extracts will provide roses with all the nutrients they need. These organic amendments also help to moderate pH imbalances and stimulate beneficial soil life. Other organic amendments favored by rose growers include greensand, black rock phosphate and alfalfa meal.